Phenylacetone → HCID 53698084, compound

Participants

Reaction Steps

Sodium hydride (10.5 g., 0.25 mole, oil dispersion) is suspended in glyme (200 ml.) and phenyl acetone (33.5 g., 0.25 mole) in glyme (25 ml.) is added dropwise with stirring. After complete addition, the mixture is heated to reflux for 0.5 hours. The mixture is cooled in a cold water bath and a solution of cinnamyl chloride (38 g., 0.25 mole) in glyme (25 ml.) is added dropwise. When addition is complete, the mixture is refluxed for 5 hours then allowed to cool. After filtration of inorganic salts and removal of solvent from the filtrate, vacuum distillation provides 44 g., b.p. 128°-134°/0.07-0.1 mm.

Provenance & Evidence