Acetic Anhydride → HCID 21539090, compound

HRID 1076337Notes

Reaction equation

HRID 1076337 reaction equation
[C:1]1([O:11][CH2:12][CH:13]([OH:20])[CH2:14][N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22]>>[C:21]([O:20][CH:13]([CH2:14][N:15]1[CH2:16][CH2:17][CH2:18][CH2:19]1)[CH2:12][O:11][C:1]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1)(=[O:23])[CH3:22]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 21539080HCID 21539080, compound

Product 1

HCID 21539090HCID 21539090, compound

Procedure

A mixture of 3 g. of 1-(5,8-dihydro-1-naphthyloxy)-3-(pyrrolidino)-2-propanol, 1.5 g. of fused acetate and 15 ml. of acetic anhydride is heated on a steam bath with occasional shaking for one hour. At the end of this time, the warm solution is poured with vigorous stirring into 100 ml. of ice water. The mixture is stirred for 10-15 minutes and the crystals of 1-(5,8-dihydro-1-naphthyloxy)-3-(pyrrolidino)-2-propyl acetate are collected, washed thoroughly with water, and purified by crystallization from alcohol.

Workup

  1. additionA mixture of 3 g
  2. additionAt the end of this time, the warm solution is poured
  3. stirringwith vigorous stirring into 100 ml
  4. stirringThe mixture is stirred for 10-15 minutes
  5. customthe crystals of 1-(5,8-dihydro-1-naphthyloxy)-3-(pyrrolidino)-2-propyl acetate are collected
  6. washwashed thoroughly with water
  7. custompurified by crystallization from alcohol

Sources & evidence

ORD record
ord-71ddb00e0d6d4e10886e7054321ef55a
Source dataset
uspto-grants-1976_05
Patent number
US03956285

Reaction notes

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