反应详情

A mixture of chloroacetamide oxime, 11.0 g. (0.10 mole), and ethyl phenyliminoacetate hydrochloride, 22 g. (0.11 mole), in 80 ml. of absolute ethanol is refluxed for one hour. After cooling, the ammonium chloride which precipitates is filtered off and the alcohol is removed in vacuo. Upon steam distillation of the residue, 7.0 gm. of 3-chloromethyl-5-benzyl-1,2,4-oxadiazole is obtained, n20 1.5386.

1. temperatureAfter cooling
2. customthe ammonium chloride which precipitates
3. filtrationis filtered off
4. customthe alcohol is removed in vacuo
5. distillationUpon steam distillation of the residue, 7.0 gm