Morpholine → HCID 622868, compound

HRID 1076354Notes

Reaction equation

HRID 1076354 reaction equation
Cl[C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>O>[O:16]1[CH2:17][CH2:18][N:13]([C:2]2[N:11]=[C:10]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH2:14][CH2:15]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 2528862,4-Dichloroquinazoline

Product 1

HCID 622868HCID 622868, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Eight grams of 2,4-dichloroquinazoline was cautiously added to 25 ml of morpholine; a vigorous reaction ensued upon mixing. After the initial reaction subsided, the mixture then was heated at 110° overnight. The reaction mixture was poured into water, and the resulting aqueous solution was extracted with several portions of ether. The combined ether extracts were washed with water, dried over anhydrous sodium sulfate, and filtered. The filtrate was evaporated to dryness and the residue was recrystallized from aqueous ethanol, giving 8 g of 2,4-bismorpholinoquinazoline; m.p. 172°-174°. The following analytical data were obtained:

Workup

  1. customa vigorous reaction
  2. additionupon mixing
  3. customAfter the initial reaction
  4. temperaturethe mixture then was heated at 110° overnight
  5. extractionthe resulting aqueous solution was extracted with several portions of ether
  6. washThe combined ether extracts were washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. filtrationfiltered
  9. customThe filtrate was evaporated to dryness
  10. customthe residue was recrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-4cf479eda1ee49cabcc2cb859e004e21
Source dataset
uspto-grants-1976_05
Patent number
US03956495

Reaction notes

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