HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → HCID 21486904, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Methoxy-2-(2-pyridyl)acetyl chloride hydrochloride | HCID 21486914 | — |
| Reactant | (RS)-Methoxy-pyridin-2-yl-acetic acid | HCID 21905598 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 21486904 | HCID 21486904 | — |
Reaction Steps
Alternatively, 2-methoxy-N,N-dimethyl-2-(2-pyridyl)acetamide is prepared by the following procedure. 2-Methoxy-2-(2-pyridyl)acetyl chloride hydrochloride, 22 g. [prepared by reacting 2-methoxy-2-(2-pyridyl)acetic acid in benzene with thionyl chloride] in 100 ml. of chloroform is added dropwise and with cooling to 50 g. of dimethylamine in 100 ml. of chloroform. The mixture is stirred for four hours, then 50 ml. of 5% aqueous sodium hydroxide is added and the chloroform solution is dried and concentrated to give 2-methoxy-N,N-dimethyl-2-(2-pyridyl)acetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03956494 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-a9fcc7d9e6ee4f7794eb9a1e6ab3435c |
| Source note | uspto-grants-1976_05 |