Cyclopropylamine → HCID 21540456, compound

HRID 1076386Notes

Reaction equation

HRID 1076386 reaction equation
[CH3:1][N:2]([CH3:13])[CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[C:4]([NH2:6])=[S:5].[CH:14]1(N)[CH2:16][CH2:15]1>O>[CH:14]1([NH:6][C:4](=[S:5])[CH:3]([N:2]([CH3:13])[CH3:1])[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 15581953HCID 15581953, compound

Product 1

HCID 21540456HCID 21540456, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-dimethylamino-2-(2-pyridyl)thioacetamide and 40% aqueous solution of cyclopropylamine is heated at reflux for 45 minutes. The mixture is cooled and water is added. The mixture is then extracted with chloroform and the extracts are dried, concentrated and the residue is recrystallized to give N-cyclopropyl-2-dimethylamino-2-(2-pyridyl)thioacetamide.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 45 minutes
  3. temperatureThe mixture is cooled
  4. extractionThe mixture is then extracted with chloroform
  5. customthe extracts are dried
  6. concentrationconcentrated
  7. customthe residue is recrystallized

Sources & evidence

ORD record
ord-f15d57a3315144b9b7c7ad24562e328f
Source dataset
uspto-grants-1976_05
Patent number
US03956494

Reaction notes

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