HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Nitro-2-acetylthiomethyloxy propane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Bis(Chloromethyl) Ether | HCID 10967 | — |
| Reactant | 2-Thiopheneacetic acid | HCID 15970 | — |
| Reactant | 1-Nitropropan-2-ol | HCID 95537 | — |
| Product | 1-Nitro-2-acetylthiomethyloxy propane | HCID 21540542 | — |
Reaction Steps
A quantity of 206 grams of 1-nitro-2-propanol was chloromethylated with 60 grams paraformaldehyde and excess hydrogen chloride according to the procedure given in Example I. The crude chloromethylether resulting was reacted with 154 grams of thiolacetic acid and then 154 grams of pyridine and distilled in vacuo after workup as described in Example I to give 123 grams of 1-nitro-2-acetylthiomethyloxy propane; structure confirmed by spectral analysis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03956500 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-005706cce1a44e408da539077e6ef666 |
| Source note | uspto-grants-1976_05 |