HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Z-Asn-Leu-OMe
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | (+)-L-Leucine methyl ester | HCID 65105 | — |
| Reactant | Z-Asn-onp | HCID 7021351 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Z-Asn-Leu-OMe | HCID 12814329 | — |
Reaction Steps
16.7 g of H-Leu-OMe and 46.0 g of Z-Asn-ONP are dissolved in 100 ml of freshly distilled dimethylformamide. The solution is allowed to stand for 19 hours at 25°C. Thereafter 1.2 liters of water are added and the crystalline precipitate is filtered off. The dipeptide derivative is dried at 40°C in vacuo and is then twice recrystallised from methanol-water. Melting point 180° - 181°C; [α]D20 = +9° (c = 2.05 in chloroform).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03956260 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-cd2a92c6e8c14acab29501d93560823d |
| Source note | uspto-grants-1976_05 |