Z-Asn-Leu-OMe → H-Asn-Leu-OMe

HRID 1076411Notes

Reaction equation

HRID 1076411 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5]>C(O)(C)(C)C.O.[Pd]>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5]

Participants

4

Reactant 1

HCID 12814329Z-Asn-Leu-OMe

Product 1

HCID 57097841H-Asn-Leu-OMe

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 714019492-Methylpropan-2-ol--water (1/1)Solvent

Procedure

15.0 g of Z-Asn-Leu-OMe are dissolved in 400 ml of t-butanol-water (9:1) and are hydrogenated in the presence of 2 g of palladium-charcoal (10 %Pd). After completion of the hydrogenation the catalyst is filtered off and the solution evaporated at 40°C. The residue is directly further used.

Workup

  1. filtrationAfter completion of the hydrogenation the catalyst is filtered off
  2. customthe solution evaporated at 40°C

Sources & evidence

ORD record
ord-1c356ee9e6404bc89f2822edbada4893
Source dataset
uspto-grants-1976_05
Patent number
US03956260

Reaction notes

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