Formic Acid → HCID 54279086, compound

HRID 1076515Notes

Reaction equation

HRID 1076515 reaction equation
[CH:1](O)=[O:2].[CH2:4]([NH:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:5].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[CH2:4]([N:6]([CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH:1]=[O:2])[CH3:5]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 10868DicyclohexylcarbodiimideHCID 17139070N-Ethyl-2-phenoxyethan-1-amine

Product 1

HCID 54279086HCID 54279086, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of formic acid (3.3 ml) and N-ethyl-N-β-phenoxyethylamine (14.5 g) in methylene chloride (100 ml) at 0°-5°C was added N,N'-dicyclohexylcarbodiimide (19.7 g) with stirring. The mixture was stirred for 18 hours at room temperature and filtered. The filtrate was evaporated in vacuo to leave an oil which was taken up in either (100 ml) and extracted with 0.4 N hydrochloric acid (2 × 25 ml) and water (2 × 25 ml). After drying, the ether was removed in vacuo to leave the above compound as an oil.

Workup

  1. stirringThe mixture was stirred for 18 hours at room temperature
  2. filtrationfiltered
  3. customThe filtrate was evaporated in vacuo
  4. customto leave an oil which
  5. extractionextracted with 0.4 N hydrochloric acid (2 × 25 ml) and water (2 × 25 ml)
  6. customAfter drying
  7. customthe ether was removed in vacuo

Sources & evidence

ORD record
ord-d41b773b2d904326ba80a2560ba253ad
Source dataset
uspto-grants-1976_05
Patent number
US03957764

Reaction notes

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