Thionyl Chloride → [(2,2,2-Trifluoroethyl)sulfanyl]acetyl chloride

HRID 1076516Notes

Reaction equation

HRID 1076516 reaction equation
S(Cl)([Cl:3])=O.[F:5][C:6]([F:14])([F:13])[CH2:7][S:8][CH2:9][C:10](O)=[O:11]>>[F:5][C:6]([F:14])([F:13])[CH2:7][S:8][CH2:9][C:10]([Cl:3])=[O:11]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 167908082-[(2,2,2-Trifluoroethyl)sulfanyl]acetic acid

Product 1

HCID 21816785[(2,2,2-Trifluoroethyl)sulfanyl]acetyl chloride

Procedure

Thionyl chloride (21.9 g, 184 mmol) and trifluoroethylmercaptoacetic acid (15.9 g, 91 mmol) were stirred together overnight. The excess reagent was removed in vacuo and the product was distilled; bp 62°-68°/20 mm.

Workup

  1. customThe excess reagent was removed in vacuo
  2. distillationthe product was distilled

Sources & evidence

ORD record
ord-c8197a9582b3471494963288a152e4a5
Source dataset
uspto-grants-1976_05
Patent number
US03957770

Reaction notes

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