Formaldehyde → HCID 21537602, compound

HRID 1076526Notes

Reaction equation

HRID 1076526 reaction equation
[C:1]([NH:4][CH2:5][CH2:6][SH:7])(=[O:3])[NH2:2].[CH2:8]=O.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>O>[O:13]1[CH2:14][CH2:15][N:10]([CH2:8][NH:2][C:1]([NH:4][CH2:5][CH2:6][SH:7])=[O:3])[CH2:11][CH2:12]1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8083MorpholineHCID 2402381-(2-sulfanylethyl)urea

Product 1

HCID 21537602HCID 21537602, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
30 °C

Procedure

1 mol of N-carbamyl cysteamine, 1 mol of formol in an aqueous 30 % solution, 1 mol of morpholine and 10cc of distilled water are mixed while stirring. The reaction is exothermic (52°C). After cooling to about 30°C, 10cc of water is added and the mixture heated to 60°C until the reactants are completely dissolved. The mixture is then evaporated and redissolved by heating it in ethanol. This mixture is then again evaporated until dry and after washing with 50cc of ether and vacuum drying on P2O5, the result is a yellow colored paste (hygroscopic)-

Workup

  1. custom(52°C)
  2. temperaturethe mixture heated to 60°C until the reactants
  3. dissolutionare completely dissolved
  4. customThe mixture is then evaporated
  5. dissolutionredissolved
  6. temperatureby heating it in ethanol
  7. customThis mixture is then again evaporated
  8. customuntil dry
  9. washafter washing with 50cc of ether and vacuum
  10. customdrying on P2O5

Sources & evidence

ORD record
ord-b5c555903dd2470b82cc2bcc8f68c7b9
Source dataset
uspto-grants-1976_05
Patent number
US03957774

Reaction notes

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