4-Chloro-3-nitrobenzophenone → [4-(4-Methylpiperazin-1-yl)-3-nitrophenyl](phenyl)methanone

Participants

Reaction Steps

N-methyl-piperazine is reacted with 3-nitro-4-chloro-benzophenone as described in Example 7 or 8 to obtain 3-nitro-4-(N-methyl-piperazino)-benzophenone (compound B11, supra with a yield of 90%. The product melts at 94°C. Analysis for C18H19N3O3 : Calculated: C 66.44% H 5.89% N 12.92% Found: C 66.28% H 5.83% N 12.79%

Provenance & Evidence