Thionyl Chloride → HCID 21537693, compound

HRID 1076550Notes

Reaction equation

HRID 1076550 reaction equation
[CH2:1]([O:3][C:4]1[N:9]=[C:8]2[N:10]([CH2:13][CH3:14])[N:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:15]([OH:17])=O)[CH3:2].S(Cl)([Cl:20])=O>>[CH2:1]([O:3][C:4]1[N:9]=[C:8]2[N:10]([CH2:13][CH3:14])[N:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:15]([Cl:20])=[O:17])[CH3:2]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21537679HCID 21537679, compound

Product 1

HCID 21537693HCID 21537693, compound

Procedure

40 g. of 6-ethoxy-1-ethyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid (0.17 mol.) and 300 ml. of thionyl chloride are refluxed for 21/2 hours. After removal of the excess thionyl chloride under vacuum, the 6-ethoxy-1-ethyl-1 H- pyrazolo[3,4-b]-pyrazine-5-carbonyl chloride is treated with hexane, filtered off and then dried at 60°, yield 41.5 g. (96%), m.p. 86°-87°.

Workup

  1. customAfter removal of the excess thionyl chloride under vacuum
  2. additionthe 6-ethoxy-1-ethyl-1 H- pyrazolo[3,4-b]-pyrazine-5-carbonyl chloride is treated with hexane
  3. filtrationfiltered off
  4. customdried at 60°

Sources & evidence

ORD record
ord-53f7ac0bdb204f169dc13028b7ea89f1
Source dataset
uspto-grants-1976_05
Patent number
US03957782

Reaction notes

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