Sodium Hydroxide → HCID 21537684, compound

HRID 1076556Notes

Reaction equation

HRID 1076556 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]2[C:17]([CH3:18])=[N:16][N:15]([CH2:19][CH3:20])[C:9]2=[N:10][C:11]=1[O:12][CH2:13][CH3:14])=[O:5])C.[OH-].[Na+]>C(O)C>[CH2:13]([O:12][C:11]1[N:10]=[C:9]2[N:15]([CH2:19][CH3:20])[N:16]=[C:17]([CH3:18])[C:8]2=[N:7][C:6]=1[C:4]([OH:5])=[O:3])[CH3:14]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53762923HCID 53762923, compound

Product 1

HCID 21537684HCID 21537684, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.78 g. of 6-ethoxy-1-ethyl-3-methyl-1H-pyrazolo-[3,4-b]pyrazine-5-carboxylic acid ethyl ester (0.01 mol.) dissolved in 20 ml. of ethanol are added to 20 ml. of aqueous sodium hydroxide (2.5 N) and the solution is allowed to stand overnight. After the vacuum removal of the alcohol, the solution is acidified with concentrated hydrochloric acid, the precipitated 6-ethoxy-1-ethyl-3methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid is filtered off, washed with water and dried at 70°, yield 2 g. (80%), m.p. 172°.

Workup

  1. customAfter the vacuum removal of the alcohol
  2. filtrationthe precipitated 6-ethoxy-1-ethyl-3methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid is filtered off
  3. washwashed with water
  4. customdried at 70°

Sources & evidence

ORD record
ord-c718dc2059724ece894b6cd9b21112b7
Source dataset
uspto-grants-1976_05
Patent number
US03957782

Reaction notes

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