Chloroacetonitrile → HCID 86733425, compound

Participants

Reaction Steps

5.8 g. of the sodium salt of 1-ethyl-6-phenyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid (0.02 mol.), 1.7 g. of chloroacetonitrile (0.22 mol.) and 70 ml. of dry dimethyl-formamide are heated in an autoclave at 120° for 5 hours. After vacuum removal of the solvent, the residual 1-ethyl-6-phenyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid, cyano-methyl ester is treated with water, filtered off, again treated with alcohol and then recrystallized from ethanol, yield 3.9 g. (64%), m.p. 102°-103°.

Provenance & Evidence