Iodoethane → HCID 53872193, compound

Participants

Reaction Steps

12.1 g. of 1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid (0.059 mol.) are added to a solution of 1.36 of sodium (0.059 mol.) in 250 ml. of absolute ethanol and is stirred for 30 minutes at room temperature. The alcohol is distilled off in vacuo and the sodium salt is dissolved in 350 ml. of dry dimethylformamide. Then, 14 g. of ethyl iodide (0.88 mol.) are added and the solution is heated in an autoclave at 120° for 10 hours. After the dimethylformamide has been removed in vacuo, the residual 1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid ethyl ester is treated with water, dried at 50° and recrystallized from hexane, yield 9.4 g. (68%), m.p. 64°-65°.

Provenance & Evidence