Chloroacetonitrile → HCID 86733426, compound

Participants

Reaction Steps

9.12 g. of the sodium salt of 1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid (0.04 mol.), 3.33 g. of chloroacetonitrile (0.056 mol.) and 90 ml. of dimethyl-formamide are stirred at 70°-80° for 12 hours. After vacuum removal of the dimethylformamide, the residue is stirred with 200 ml. of ether and filtered. The ethereal filtrate is evaporated and the residual 1-ethyl-6-methyl-1H-pyrazolo[3,4-b]-pyrazine-5-carboxylic acid, cyanomethyl ester is recrystallized from hexane, yield 3.76 g. (38%), m.p. 83°-84°. A polymorphous form melts at 111°-112°.

Provenance & Evidence