2-Aminopyrimidine → HCID 21486767, compound

Participants

Reaction Steps

To a solution of 154.0 g of 3-(2-bromo-4-methylthiophenyl)propyl bromide in 400 ml of dry xylene, is added a solution of 70.0 g of 2-aminopyrimidine in 300 ml of dry xylene and the mixture is heated under reflux for about 18 hours. The cooled xylene solution is decanted from the crystalline solid, the solid is triturated with 200 ml of 2-propanol and filtered to give 117.0 g of crude product. Recrystallization of the latter from 2-propanol gives about 98.0 g of 2-amino-1-[3-(2-bromo-4-methylthiophenyl)propyl]-pyrimidinium bromide.

Provenance & Evidence