Carbamic acid, ethyl ester → HCID 178421810, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 17.85 g of 2-amino-3-(o-fluorobenzoyl)-5-methylthiophene, 25.69 g of ethyl carbamate and 1.55 g of zinc chloride is heated at 200°C for 30 minutes. After cooling, the reaction mixture is washed with chloroform, then with water, and filtered to give 4-(o-fluorophenyl)-6-methyl-1,2-dihydrothieno[2,3-d]pyrimidin-2-one as crystalline solids. Recrystallization from chloroform-ethanol gives crystals having a melting point of 282° - 284°C.

Provenance & Evidence