Carbamic acid, ethyl ester → HCID 178517451, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 500 mg of 2-amino-3-(o-fluorobenzoyl)thiophene, 760 mg of ethyl carbamate and 46 mg of zinc chloride is heated at 200°C for 1 hour. After cooling, the reaction mixture is washed with chloroform and filtered to give crystals, which are disolved in acetone and filtered. The filtrate is condensed under reduced pressure to give 4-(o-fluorophenyl)-1,2-dihydrothieno[2,3-d]pyrimidin-2-one as crystals having a melting point of 254° - 256°C. Recrystallization from acetone gives crystals having a melting point of 278° - 279°C (decomp.)

Provenance & Evidence