Pyridine → HCID 12426507, compound

Participants

Reaction Steps

To a mixture of 4.50 g of 2-amino-3-benzoyl- 4-methylthiophene, 4.5 g of pyridine and 450 ml of anhydrous ether is added dropwise 4.50 g of acetyl chloride. Then the reaction mixture is stirred under reflux for 5 hours. After cooling, the reaction mixture is poured into water. The ether layer is separated and washed with water, and dried over sodium sulfate. The solvent is removed under reduced pressure to give an oily residue, which is crystallized from ether to give 2-acetylamino-3-benzoyl-4-methylthiophene having a melting point of 106° - 107°C.

Provenance & Evidence