Carbamic acid, ethyl ester → HCID 21537717, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.5 g of 2-methylamino-3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophene, 1.5 g of ethyl carbamate and 0.11 g of zinc chloride is heated at 200°C for 1 hour. After cooling, the reaction mixture is extracted with chloroform. The chloroform extracts are combined, washed with water, dried over sodium sulfate and concentrated to dryness under reduced pressure and residue is recrystallized from ethanol to give 1-methyl-4-phenyl-1,2,5,6,7,8-hexahydrobenzothieno[ 2,3-d]pyrimidin-2-one as crystals having a melting point of 215° - 216°C.

Provenance & Evidence