反应详情

To a mixture of 35 g of 2-amino-3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophene, 35 g of pyridine and 1950 ml of anhydrous ether is added dropwise 35 g of acetyl chloride. Then the reaction mixture is stirred under reflux for 3 hours. After cooling, the reaction mixture is poured into water. The ether layer is separated and washed with water, and dried over sodium sulfate. The solvent is removed under reduced pressure to give an oily residure, which is crystallized from ether to give 2-acetylamino-3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophene having a melting point of 116° - 119°C.

1. temperatureunder reflux for 3 hours
2. temperatureAfter cooling
3. customThe ether layer is separated
4. washwashed with water
5. dry with materialdried over sodium sulfate
6. customThe solvent is removed under reduced pressure
7. customto give an oily residure, which
8. customis crystallized from ether