Potassium Hydroxide → HCID 16486755, compound

Participants

Reaction Conditions

Reaction Steps

To solution of 5.0 g of N-methyl-2-acetylamino-3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophene in 120 ml of ethanol, is added 2.7 g of potassium hydroxide in 60 ml of water. The mixture is heated at 95°C for 4 hours, evaporated under reduced pressure to a residue. Water is added to the residue and extracted with chloroform. The chloroform extracts are washed with water, dried over sodium sulfate, then evaporated under reduced pressure to give crystals, which are recrystallized from ethanol to give 2-methylamino-3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophene as crystals having a melting point of 127.5° - 129.5°C.

Provenance & Evidence