反应详情

温度

95 °C

To a solution of 1.255 g of N-methyl-2-acetylamino-3-propionylthiophene in 25 ml of ethanol, is added 0.45 g of potassium hydroxide in 10 ml of water. The mixture is heated at 95°C for 1 hour, evaporated under reduced pressure to a residue. Water is added to the residue and extracted with dichloromethane. The dichloromethane extracts are washed with water, dried over sodium sulfate, then evaporated under reduced pressure to give an oil. The residual oil is chromatographed on silica gel, using chloroform as an eluent to give 2-methylamino-3-propionylthiophene as an oil.

1. customevaporated under reduced pressure to a residue
2. additionWater is added to the residue
3. extractionextracted with dichloromethane
4. washThe dichloromethane extracts are washed with water
5. dry with materialdried over sodium sulfate
6. customevaporated under reduced pressure
7. customto give an oil
8. customThe residual oil is chromatographed on silica gel