Potassium Hydroxide → HCID 13229177, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 26.0 g of 2-(N-methylacetylamino)-3-(o-chlorobenzoyl)-5-ethylthiophene in 520 ml of ethanol, is added 5.85 g of potassium hydroxide in 164 ml of water. The mixture is heated at 95°C for 1 hour, then evaporated under reduced pressure to a residue. Water is added to the residue and extracted with dichloromethane. The dichloromethane extracts are washed with water, dried over sodium sulfate, then evaporated under reduced pressure to give crystals, which are chloromatographed on silica gel using chloroform as an eluent to give 15.26 g of 2-(N-methylamino)-3-(o-chlorobenzoyl)-5-ethylthiophene as crystals having a melting point of 100° - 102°C (after recrystallization from ether); yield 67.5%.

Provenance & Evidence