Hydrochloric Acid → HCID 21537750, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.5 g of 2-(N-methylacetylamino)-3-(o-fluorobenzoyl)-5-chlorothiophene in 7 ml of ethanol is added 4 ml of 6 N aqueous hydrochloric acid. The mixture is heated at 90°C for 2 hours, evaporated under reduced pressure to a residue, neutralized with aqueous ammonia, then extracted with ether. The ether extracts are washed with water, dried over sodium sulfate, when evaporated under reduced pressure to a oil, which is chromatographed on silica gel using chloroform as an eluent to give 2-(N-methylamino)-3-(o-fluorobenzoyl)-5-chlorothiophene as crystals having a melting point of 93° - 94°C.

Provenance & Evidence