2H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo- → HCID 131710239, compound

HRID 1076618Notes

Reaction equation

HRID 1076618 reaction equation
[NH2:1][N:2]1[C:11]([OH:19])([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([F:20])[CH:9]=2)[N:4]=[CH:3]1.[C:21]1(=[O:35])[N:25]([CH2:26][C:27](Cl)=[O:28])[C:24](=[O:30])[C:23]2=[CH:31][CH:32]=[CH:33][CH:34]=[C:22]12>N1C=CC=CC=1>[Cl:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:11]([C:10]1[CH:9]=[C:8]([F:20])[CH:7]=[CH:6][C:5]=1[N:4]([CH:3]=[N:2][NH:1][C:27](=[O:28])[CH2:26][N:25]1[C:21](=[O:35])[C:22]2[C:23](=[CH:31][CH:32]=[CH:33][CH:34]=2)[C:24]1=[O:30])[C:27](=[O:28])[CH2:26][N:25]1[C:24](=[O:30])[C:23]2[C:22](=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:21]1=[O:35])=[O:19]

Participants

4

Reactant 2

HCID 812422H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-HCID 21537286HCID 21537286, compound

Product 1

HCID 131710239HCID 131710239, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In the manner given in Example 1, 3-amino-6-fluoro-3,4-dihydro-4-hydroxy-4-(o-chlorophenyl)quinazoline with pyridine is reacted with α-phthalimidoacetyl chloride to give 1,3-dioxo-2-isoindolineacetic acid, [[N-[2-(o-chlorobenzoyl)-4-fluorophenyl]-1,3-dioxo-2-isoindolineacetamido]methylene]hydrazide.

Sources & evidence

ORD record
ord-bb6cc4c926104859b598744ed1224129
Source dataset
uspto-grants-1976_05
Patent number
US03957761

Reaction notes

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