2H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo- → HCID 131710240, compound

HRID 1076619Notes

Reaction equation

HRID 1076619 reaction equation
[NH2:1][N:2]1[C:11]([OH:19])([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:20]([F:23])([F:22])[F:21])[CH:9]=2)[N:4]=[CH:3]1.[C:24]1(=[O:38])[N:28]([CH2:29][C:30](Cl)=[O:31])[C:27](=[O:33])[C:26]2=[CH:34][CH:35]=[CH:36][CH:37]=[C:25]12>N1C=CC=CC=1>[Cl:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:11]([C:10]1[CH:9]=[C:8]([C:20]([F:23])([F:22])[F:21])[CH:7]=[CH:6][C:5]=1[N:4]([CH:3]=[N:2][NH:1][C:30](=[O:31])[CH2:29][N:28]1[C:24](=[O:38])[C:25]2[C:26](=[CH:34][CH:35]=[CH:36][CH:37]=2)[C:27]1=[O:33])[C:30](=[O:31])[CH2:29][N:28]1[C:27](=[O:33])[C:26]2[C:25](=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:24]1=[O:38])=[O:19]

Participants

4

Reactant 2

HCID 812422H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-HCID 21537317HCID 21537317, compound

Product 1

HCID 131710240HCID 131710240, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In the manner given in Example 1, 3-amino-6-trifluoromethyl-3,4-dihydro-4-hydroxy-4-(o-chlorophenyl)quinazoline with pyridine is reacted with α-phthalimidoacetyl chloride to give 1,3-dioxo-2-isoindolineacetic acid, [[N-[2-(o-chlorobenzoyl)-4-(trifluoromethyl)phenyl]-1,3-dioxo-2-isoindolineacetamido]methylene]hydrazide.

Sources & evidence

ORD record
ord-24c599010be04f73acd05470687035b4
Source dataset
uspto-grants-1976_05
Patent number
US03957761

Reaction notes

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