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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1076636Generated: November 2, 2026

Hydrazine hydrate (1:1) → 8-nitro-1-(pyrrolidinomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

https://huagongshe.com/reaction/1076636

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrazine hydrate (1:1)HCID 24654—
Reactant2'-chloro-5-nitro2-[3-(pyrrolidinomethyl)-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenoneHCID 21537271—
SolventEthanolHCID 702—
Product8-nitro-1-(pyrrolidinomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepineHCID 21537300—

Reaction Steps

In the manner given in Example 27, 2'-chloro-5-nitro2-[3-(pyrrolidinomethyl)-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone is heated in ethanol with hydrazine hydrate to give 8-nitro-1-(pyrrolidinomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03957761
Source datasetuspto-grants-1976_05
ORD IDord-34b39599fb554100a4b3c1db6bc7d92d
Source noteuspto-grants-1976_05