2-Aminopyridine → HCID 21495113, compound

HRID 1076655Notes

Reaction equation

HRID 1076655 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[Cl:8][CH2:9][S:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=1[Br:18]>C1C=CC=CC=1>[Cl-:8].[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N+:3]=1[CH2:9][S:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=1[Br:18]

Participants

4

Reactant 2

HCID 104392-AminopyridineHCID 214951322-Bromo-4-chloro-1-[(chloromethyl)sulfanyl]benzene

Product 1

HCID 21495113HCID 21495113, compoundYield 85.9%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 18.8 g of 2-aminopyridine in 180 ml of benzene is added 54.6 g of the product from example 30, and the mixture stirred and heated under reflux for about 12 hours. The cooled mixture is filtered to give about 62.8 g of the named compound, mp about 240°-242°.

Workup

  1. temperatureheated
  2. temperatureunder reflux for about 12 hours
  3. filtrationThe cooled mixture is filtered

Sources & evidence

ORD record
ord-c6c070c8653c4c429b48797e4b46002b
Source dataset
uspto-grants-1976_05
Patent number
US03957799

Reaction notes

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