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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1076660Generated: November 3, 2026

5-Nitrothiophene-2-carboxaldehyde → HCID 54253561, compound

https://huagongshe.com/reaction/1076660

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Nitrothiophene-2-carboxaldehydeHCID 78281—
Reactant3-Chloro-6-hydrazinopyridazineHCID 100787—
SolventEthanolHCID 702—
ProductHCID 54253561HCID 54253561—

Reaction Steps

3-Hydrazino-6-chloropyridazine was condensed with 5-nitro-2-thiophene-aldehyde in ethanol and the 3-(5-nitro-2-thienylidene-hydrazino)-6-chloropyridazine (m.p. 306° - 308°C. decomp.) thus obtained was cyclized in glacial acetic acid with lead tetraacetate to give 3-(5-nitro-2-thienyl)-6-chloro-s-triazolo[4,3-b]pyridazine (m.p. 215° - 217°C.) and this subsequently reacted with hydrazine hydrate in isopropanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03957766
Source datasetuspto-grants-1976_05
ORD IDord-856116b83241421daa92ee07655f36d4
Source noteuspto-grants-1976_05