1-Methylpiperazine → HCID 21537484, compound

Participants

Reaction Steps

0.9 g. 3-(5-nitro-2-furyl)-6-(ethyoxymethyleneamino)-s-triazolo[4,3-b]pyridazine were dissolved in 20 ml. hot dioxan and mixed, while stirring, with 0.6 g. N-methyl-piperazine at 50°C. After 15 minutes, the crystals formed were filtered off with suction and recrystallized from 15 ml. of a mixture of 70% dioxan and 30 ml. dimethyl formamide. There was thus obtained 0.77 g. 3-(5-nitro-2-furyl)-6-(4-methyl-1-piperazinyl methyleneamino)-s-triazolo[4,3-b]pyridazine, which had a melting point of 247° - 248°C.

Provenance & Evidence