Hydrochloric Acid → HCID 21537527, compound

Participants

Reaction Steps

6.8 g. crude 2-hydrazino-4-amino-5-methyl-pyrimidine (m.p. 174° - 175°C.), which was prepared by treating 8 g. 2-chloro-4-methyl-pyrimidine with 40 ml. hydrazine hydrate for 1.5 hours at 100°C., were dissolved in a mixture of 79'ml. water and 37 ml. 2N hydrochloric acid, a solution of 8.3 g. 5-nitro-furan-2-aldehyde in 116 ml. methanol then added thereto, the reaction mixture left to stand for 1 hour at ambient temperature and the precipitated crystals filtered off with suction, washed with 50% aqueous methanol and then with ether, there thus being obtained 12.7 g. of the crude hydrazone, which had a melting point of 264° - 268°C.

Provenance & Evidence