Diazomethane → HCID 21408257, compound

HRID 1076666Notes

Reaction equation

HRID 1076666 reaction equation
[N+](=[CH2:3])=[N-].[CH2:4]([C:6]1[S:7][C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=1)[CH3:5]>C(Cl)Cl>[CH2:4]([C:6]1[S:7][C:8]([C:11]([O:13][CH3:3])=[O:12])=[CH:9][N:10]=1)[CH3:5]

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 2077555-Thiazolecarboxylic acid, 2-ethyl-

Product 1

HCID 21408257HCID 21408257, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of diazomethane in methylene chloride was added to a suspension of 10.45 g of 2-ethyl-thiazole-5-carboxylic acid in 30 ml of methylene chloride until efferversence stopped and the methylene chloride was distilled. The oily residue was chromatographed over silica and was eluted with a 1:1 mixture of benzene-ethyl acetate to obtain 11.3g of methyl 2-ethyl-thiazole-5-carboxylate.

Workup

  1. distillationthe methylene chloride was distilled
  2. customThe oily residue was chromatographed over silica
  3. washwas eluted with a 1:1 mixture of benzene-ethyl acetate

Sources & evidence

ORD record
ord-100932b015b74f0e9c2dd3c99b8d41b0
Source dataset
uspto-grants-1976_05
Patent number
US03957809

Reaction notes

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