HCID 21537926, compound → HCID 178422220, compound

HRID 1076694Notes

Reaction equation

HRID 1076694 reaction equation
[CH3:1][CH:2]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:5]2=[N:6][NH:7][CH:8]([C:9]3[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=3)[CH:4]2[CH2:3]1>[O-2].[O-2].[Mn+4].C1C=CC=CC=1>[CH3:1][CH:2]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:5]2=[N:6][NH:7][C:8]([C:9]3[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=3)=[C:4]2[CH2:3]1

Participants

4

Reactant 1

HCID 21537926HCID 21537926, compound

Product 1

HCID 178422220HCID 178422220, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 241BenzeneSolvent

Procedure

Into a flask equiped with a magnetic stirring bar is charged 5.0 grams of the 5-methyl-3-(4-pyridyl)-3,3a,4,5-tetrahydro-2H-naphtho[1,2-c]pyrazole prepared as in example 3, 25 grams of activiated manganese dioxide and 150 ml of dry benzene. The mixture is stirred for about 12 hours at room temperature, after which the manganese salts are filtered off and the solvent removed in vacuo. The solid is crystallized from ethanol to yield 4,5-dihydro-2-methyl-3-(4-pyridyl)-2H-naphtho.[1,2-c]pyrazole.

Workup

  1. customInto a flask equiped with a magnetic stirring bar
  2. additionis charged
  3. filtrationafter which the manganese salts are filtered off
  4. customthe solvent removed in vacuo
  5. customThe solid is crystallized from ethanol
  6. customto yield 4,5-dihydro-2-methyl-3-(4-pyridyl)-2H-naphtho

Sources & evidence

ORD record
ord-3bc0779e5b2d4340b2c0166a7998118a
Source dataset
uspto-grants-1976_05
Patent number
US03957816

Reaction notes

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