Ammonia → HCID 21537998, compound

Participants

Reaction Steps

In a manner to that in Example 1, 106.6 g of 3-amino-4-cyano-1-benzyl-2-methyl-3-pyrroline in 200 ml of ethanol and 200 g of gaseous ammonia is hydrogenated, in the presence of 6 g of Raney nickel containing 2% of palladium, for 4 hours at 120°C at a pressure of 100 atmospheres. The crude amine contains, on the basis of the gas-chromatogram, about 10% of low-boiling by-product. Fractional distillation through a packed column yields 52.1 g (47.6%), B.P. 126°-127°C/0.3 mm Hg.

Provenance & Evidence