HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → Ciclazindol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 178479601 | HCID 178479601 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ciclazindol | HCID 37825 | — |
Reaction Steps
3-(m-Chlorophenyl)-2-(3-chloropropylamino)-3H-indol-3-ol hydrochloride (0.742 g.) was dissolved in methanol (10 ml.) containing sodium methoxide (0.27 g.) and left at room temperature for 64 hours. The solution was evaporated to a foam which was triturated with water. The product was isolated as a white powder (546 mg.), m.p. 186°-187°C. Recrystallisation from acetonitrile raised the melting point to 190°-192°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03957819 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-84e5b253bdbc4c1c8d49e478bc6307d6 |
| Source note | uspto-grants-1976_05 |