HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178520828, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Reactant | 3-Hydroxy-3-phenyl-1,3-dihydroindol-2-one | HCID 15806 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 178520828 | HCID 178520828 | — |
Reaction Steps
3-Phenyl-3-hydroxy-3H-indol-2-one (4.5 g.) was heated under reflux with 3-aminopropanol (6.0 g.) in xylene (100 ml.) and toluene-p-sulphonic acid (150 mg) in an apparatus fitted with a water separator. After 24 hours the reaction mixture was cooled. The product crystallised and was filtered off and recrystallised from methanol to give the title compound, 3.81 g., m.p. 215°-217°C. (Found C, 72.4; H, 6.7; N. 9.9, C17H18N2O2 requires C, 72.3; H, 6.4; N, 9.9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03957819 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-564097dba93443b88aeeb8643f51b32a |
| Source note | uspto-grants-1976_05 |