Sodium Methoxide → 10-Phenyl-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol

HRID 1076714Notes

Reaction equation

HRID 1076714 reaction equation
Cl[CH2:2][CH2:3][CH2:4][NH:5][C:6]1[C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)([OH:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1.C[O-].[Na+]>>[C:16]1([C:14]2([OH:15])[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:7]3[CH2:2][CH2:3][CH2:4][N:5]=[C:6]23)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 10942334Sodium MethoxideHCID 178514949HCID 178514949, compound

Product 1

HCID 1507593810-Phenyl-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol

Procedure

Cyclisation of 2-(3-chloropropylamino)-3-phenyl-3H-indol-3-ol with sodium methoxide by a process analogous to that described in Example 3 gives 2,3,4,10-tetrahydro-10-phenylpyrimido[1,2-a]indol-10-ol.

Sources & evidence

ORD record
ord-00e64bab41104b47ab09a8c090cdd739
Source dataset
uspto-grants-1976_05
Patent number
US03957819

Reaction notes

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