Thionyl Chloride → HCID 178515065, compound

HRID 1076718Notes

Reaction equation

HRID 1076718 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2([OH:22])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=[C:9]2[NH:17][CH2:18][CH2:19][CH2:20]O)[CH:5]=[CH:6][CH:7]=1.S(Cl)([Cl:25])=O>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2([OH:22])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=[C:9]2[NH:17][CH2:18][CH2:19][CH2:20][Cl:25])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 178520831HCID 178520831, compound

Product 1

HCID 178515065HCID 178515065, compound

Procedure

Reaction of 3-(m-fluorophenyl-2-(3-hydroxypropylamino)-3H-indol-3-ol with thionylchloride by a procedure analogous to that described in Example 2 gives 3-(m-fluorophenyl)-2-(3-chloropropylamino)-3H-indol-3-ol.

Sources & evidence

ORD record
ord-b3243d9ff0414650857f11893b03e626
Source dataset
uspto-grants-1976_05
Patent number
US03957819

Reaction notes

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