Triethylamine → HCID 21537802, compound

Participants

Reaction Steps

To a solution containing 17.62 g (0.1 mole) of N-benzyl-piperazine in 100 ml of xylene were added 23.05 g (0.1 mole) of 3,3-diphenylpropyl chloride and 10.1 g (0.1 mole) of triethylamine, and the resulting solution was heated at the refluxing temperature for 2.5 hours. The reaction liquid was left to cool, and the triethylamine hydrochloride which precipitated was filtered out. Then, dry hydrogen chloride gas was passed through this solution, while the solution was cooled so as to precipitate 1-(3,3-diphenyl-propyl)-4-benzylpiperazine dihydrochloride. The crystals were recovered by filtration, and recrystallized from an ethanol and ether mixed solvent to obtain 37.7 g of pure crystals (85.0% yield) with a melting point of 187°- 188°C.

Provenance & Evidence