Sodium Hydroxide → HCID 68142496, compound

Participants

Reaction Steps

The amount of 6 g (0.011 mole) of 1-(3,3-diphenylpropyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride was dissolved in 50 ml of water, and 20 ml of a 10% sodium hydroxide solution was added. Then, the resulting solution was extracted three times, each time with 20 ml of ether, the ether layers combined, washed with water, and concentrated to a total volume of 10 ml. By adding a methanol-ether solution of 2.7 g (0.013 mole) of citric acid monohydrate to 5 ml of this concentrated solution, 4.4 g (92.7% yield) of 1-(3,3-diphenylpropyl)-4-(2,3,4-trimethoxybenzyl)piperazine dicitrate monohydrate with a melting point of 86° -92°C was obtained.

Provenance & Evidence