Fumaric Acid → HCID 21537824, compound

HRID 1076790Notes

Reaction equation

C(O)(=O)/C=C/C(O)=[O:5].O.[C:10]([OH:22])(=[O:21])[CH2:11][C:12](CC(O)=O)([C:14]([OH:16])=[O:15])O.[C:23]([OH:35])(=[O:34])[CH2:24][C:25](CC(O)=O)([C:27]([OH:29])=[O:28])O.[C:36]1([CH:42]([C:64]2[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=2)[CH2:43][CH2:44][N:45]2[CH2:50][CH2:49][N:48]([CH2:51][C:52]3[CH:57]=[CH:56][C:55]([O:58][CH3:59])=[C:54]([O:60][CH3:61])[C:53]=3[O:62][CH3:63])[CH2:47][CH2:46]2)[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[OH2:5].[C:10]([OH:22])(=[O:21])/[CH:11]=[CH:12]/[C:14]([OH:16])=[O:15].[C:23]([OH:35])(=[O:34])/[CH:24]=[CH:25]/[C:27]([OH:29])=[O:28].[C:64]1([CH:42]([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:43][CH2:44][N:45]2[CH2:46][CH2:47][N:48]([CH2:51][C:52]3[CH:57]=[CH:56][C:55]([O:58][CH3:59])=[C:54]([O:60][CH3:61])[C:53]=3[O:62][CH3:63])[CH2:49][CH2:50]2)[CH:65]=[CH:66][CH:67]=[CH:68][CH:69]=1

Participants

Reactant 2

HCID 444972Fumaric Acid

HCID 68142496HCID 68142496, compound

Product 1

HCID 21537824HCID 21537824, compoundYield 92.1%

Procedure

By adding a methanol-ether solution of 1.75 g (0.015 mole) of fumaric acid to 5 ml of the concentrated ether solution described above 3.6 g (92.1% yield) of 1-(3,3-diphenylpropyl)-4-(2,3,4-trimethoxybenzyl)piperazine difumarate monohydrate with a melting point of 196° -197°C was obtained.

Sources & evidence

ORD record: ord-989d736b5bf44961821c28526edda9b4
Source dataset: uspto-grants-1976_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03957790

Reaction notes

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