HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-cyano-3-(2-nitrophenyl)prop-2-enoate → 2,6-Diamino-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-isopropyl ester 5-ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-cyano-3-(2-nitrophenyl)prop-2-enoate | HCID 231461 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Amidinoacetic acid isopropyl ester | HCID 12391080 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,6-Diamino-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-isopropyl ester 5-ethyl ester | HCID 70631614 | 54% |
Reaction Steps
Upon heating a solution of 12.3 g 2-nitrobenzylidenecyanoacetic acid ethyl ester, 7.2 g amidinoacetic acid isopropyl ester and 0.6 g sodium ethylate in 150 ml ethanol for 4 hours, 2,6-diamino-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-isopropyl ester 5-ethyl ester of m.p. 110°C is obtained. Yield: 54% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03957998 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-b65248279149428091b588e11e8618b9 |
| Source note | uspto-grants-1976_05 |