Methyl Isocyanate → HCID 54435643, compound

HRID 1076887Notes

Reaction equation

HRID 1076887 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:26])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:16][CH2:15][C:14]3([C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH:18]([OH:25])[CH2:17]3)[CH2:13]2)=[CH:4][CH:3]=1.[CH3:27][N:28]=[C:29]=[O:30]>C(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:26])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:16][CH2:15][C:14]3([C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH:18]([O:25][C:29](=[O:30])[NH:28][CH3:27])[CH2:17]3)[CH2:13]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 54334119HCID 54334119, compound

Product 1

HCID 54435643HCID 54435643, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

9.0 g of p-fluoro-4-(3-hydroxyspiro[indan-1,3'-pyrrolidin]-1'-yl) butyrophenone and 2.0 g of methyl isocyanate are dissolved in 50 cc of methylene chloride. After allowing the reaction solution to stand at room temperature for 20 hours, it is concentrated by evaporation, and the resulting oil is converted into the hydrogen fumarate. After recrystallization from ethanol/ether, the hydrogen fumarate of the title compound has a M.P. of 167°-169°.

Workup

  1. concentrationit is concentrated by evaporation
  2. customAfter recrystallization from ethanol/ether

Sources & evidence

ORD record
ord-5e91ce2a0b4d4becb9926a837a815c32
Source dataset
uspto-grants-1976_05
Patent number
US03958003

Reaction notes

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