Acetic Anhydride → HCID 21538621, compound

Participants

Reaction Steps

7.5 g of (1RS,3RS)-p-fluoro-4-(3-hydroxy-spiro[indane-1,3'-pyrrolidin]-1'-yl)butyrophenone are stirred at room temperature for 20 hours together with 15 cc of pyridine and 15 cc of acetic anhydride. The reaction mixture is then poured on ice, is made alkaline with 2 N caustic soda solution and is extracted thrice with 100 cc amounts of ether. The crude title compound obtained as oily residue after concentrating the ether phase by evaporation, is converted into the hydrogen fumarate form, which is recrystallized from ethanol/ether. M.P. of the hydrogen fumarate form of the title compound: 168°-170°.

Provenance & Evidence