Sodium Dichromate → 2,7-Bis(4-piperidinobutyryl)xanthone

Participants

Reaction Steps

To a solution of 9.8 g (0.025 mole) of 2,7-bis(4-piperidinobutyryl)xanthene in 300 ml. of glacial acetic acid was added 9.8 g (0.033 mole) of sodium dichromate over 1/2 hour. The mixture was stirred for 11/2 hours, refluxed for 1 hour, then evaporated to near dryness, cooled, diluted with water and made alkaline with 28% NH4OH solution. The resulting solid was extracted with methylene chloride, chromatographed on alumina using methylene chloride as the eluant, recrystallized from heptane and dried under vacuum at 60°C. to give the desired product. M.P. 93°-95°C.

Provenance & Evidence