Ethanol → HCID 22484390, compound

Participants

Reaction Conditions

Reaction Steps

In 50 volume parts of water are dissolved 19 parts of TRH monohydrate and 7.5 parts of L-tartaric acid, and while the solution is warmed to 70°C, ethanol is added in installments. Immediately after a slight turbidity is observed, the temperature is gradually brought down to room temperature, at which temperature the solution is allowed to stand for 3 days. Then, the solution is cooled to 10°C and allowed to stand for 2 days to allow crystallization to be completed. The crystals thus obtained are harvested by filtration, washed with hot ethanol and dried under reduced pressure at 50°C for 1 hour and at 80°C for 5 hours. The described procedure yields 18 parts of TRH tartrate-water as crystals melting at 127°C-130°C. [α]D 24 =-49.90°(c=1.05 in water)

Provenance & Evidence